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Small leucine-rich proteoglycan [SLRP] decorin is upregulated in dystrophic mouse models and downregulated in human Duchenne muscular dystrophy [DMD]. This pilot study looks at decorin's localization patterns in skeletal muscle histology to see if the regulation of this SLRP could play a role in DMD pathology and possibly present as a therapeutic target for DMD. Findings from this study show trends of different levels of decorin expression amongst our dystrophic mouse genotypes and treatment groups, warranting further study of decorin and its role in DMD pathology.