Effect of Oxygen Desaturation from Carbon Monoxide Inhalation on Erythrocytic 2,3-DPG

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1979-03

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Abstract

Erythrocytic 2,3-diphosphoglycerate (2,3-DPG), in response to carbon monoxide (CO) hypoxemia, was studied in 12 rabbits exposed to 250 ppm CO for 3 hours. Each animal served as its own control. Individual determinations of carboxyhemoglobin, arterial oxygen content, oxygen saturation, and 2,3-DPG were made before and immediately after exposures to both CO and normal air. After CO inhalation, there was no significant change in 2,3-DPG despite an average reduction of 22% in arterial oxygen saturation. Moreover, there was no significant correlation between individual oxygen desaturations and changes in 2,3-DPG. The data imply that the 2,3-DPG mechanism offers little or no compensation for this form of hypoxia.

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Author Institution: Biiology Department, University of Dayton

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The Ohio Journal of Science. v79, n2 (March, 1979), 81-83