INVESTIGATION OF MEMBRANE PEPTIDES BY TWO-DIMENSIONAL INFRARED SPECTROSCOPY

Thumbnail Image

Files

abstract.gif (12.22 KB)
OSU Mol Spec 2.ppt (3.57 MB)
Slide1.GIF (42.3 KB)
Slide2.GIF (156.09 KB)
Slide3.GIF (63.05 KB)

Date

2009

Authors

Journal Title

Journal ISSN

Volume Title

Publisher

Ohio State University

Research Projects

Organizational Units

Journal Issue

Abstract

Two-dimensional infrared spectroscopy (2D IR) is a useful tool for studying the structure of membrane peptides. Isotope labeling individual amino acids with 13C=18O decouples the isotope labeled amide I from the other amide I modes in the peptide. Work has been done on both the M2 ion channel and ovispirin antimicrobial peptide, studying the diagonal linewidths of the isotope labeled amide I. The diagonal linewidth of the isotope labeled amide I gives information about the local environment of that residue, which in turn gives structural information about the membrane peptide.

Description

Author Institution: Department of Chemistry, University of Wisconsin Madison, 1101 University Ave, Madison, WI 53706

Keywords

Citation

URI

http://hdl.handle.net/1811/38201

Collections

Abstracts of OSU International Symposium on Molecular Spectroscopy 2000-2009