Magnetic Resonance Imaging Elastography Derived Isotropic and Anisotropic Stiffness Estimation in Healthy Human Kidney
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Date
2024-03
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Abstract
Background: Chronic Kidney Disease (CKD) can lead to a long, costly, and painful process through diagnosis and prognosis. DTI and MRE are MRI based techniques that may offer more robustness to current kidney diagnostic and prognostic methods.
Purpose: To compare isotropic and anisotropic stiffness of the cortex, medulla, and whole kidney.
Methods: A spin-echo echo planar (SE-EPI) MRE sequence was used to obtain coronal slices of the kidneys. Two soft, passive drivers, positioned on the lower back at the location of the kidneys, were used to introduce 60 Hz vibrations in the kidneys. A SE-EPI DTI sequence was used to obtain coronal slices of the kidneys. MRE Wave images and DTI images were processed to obtain isotropic stiffness and anisotropic stiffness data. Isotropic and anisotropic stiffness values were compared using a one-way ANOVA. Pearson’s correlation coefficient was calculated for anisotropic stiffness over isotropic stiffness. A p-value <0.05 was considered statistically significant.
Results: MRE-derived isotropic and the longitudinal anisotropic stiffness measurements were significantly different. The correlation coefficients between MRE-derived isotropic stiffness measurements and anisotropic stiffness measurements were high for all longitudinal components of anisotropic stiffness measurements and several transverse components of anisotropic stiffness.
Conclusion: Anisotropic stiffness measurements derived from MRE and DTI imaging are promising techniques that may bolster current diagnostic and prognostic methods.
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Engineering: 2nd Place (The Ohio State University Edward F. Hayes Advanced Research
Forum)
Keywords
MRE, DTI, Tractography, Anisotropic Stiffness