Development of tools for the analysis of DNA double strand break repair
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Date
2019-05
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The Ohio State University
Abstract
Repair of DNA double strand breaks are very important in molecular biology. They play a role in
the stability of a genome, and if not repaired quickly and correctly can lead to serious problems
for the cell. These problems include genomic instability, chromosomal deletions, duplications,
and inversions to name a few. Incorrect repair of these breaks leads to accumulation of DNA
damage, so it is important to understand the mechanisms by which these breaks occur and are
repaired. Development of new molecular methods is critical to helping researchers determine
mechanisms of repair. Here I outline several assays that we have designed for the analysis of in
vivo DNA double strand break repair.