Effect of Selected Amino Acid and Amino Sugar Derivatives on the Immune Response

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The low molecular weight amino acids, N-a-benzyloxycarbonyl-L-lysine and L-lysine, and the amino sugar derivative, N-acetyl-D-glucosamine, were examined for effects on the immune response of mice to sheep erythrocytes. Treatment dosages of 1000, 100, 50 and 10 mg/kg of the test compounds did not alter the body weight, organ weight or peripheral leucocyte count of test mice. Mice given N-a-benzyloxycarbonyl- L-lysine demonstrated significant increases or decreases in the splenic plaqueforming cell response to sheep erythrocytes depending on the treatment regimen employed. Animals given N-acetyl-D-glucosamine showed an increase in the splenic plaque forming cell response while those receiving L-lysine had no detectable alteration.


Author Institution: Division of Medicinal Chemistry, College of Pharmacy, Department of Microbiology and Department of Microbiology, College of Biological Sciences, Ohio State Univ.



The Ohio Journal of Science. v78, n2 (March, 1978), 100-102