CONFORMATIONAL ANALYSIS OF THE NEUROTRANSMITTER SEROTONIN
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Date
2006
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Publisher
Ohio State University
Abstract
Serotonin (5-hydroxytryptamine) is an important neurotransmitter linked to depression. It is used by the pharmaceutical industry in anti-depression drugs. We will report on a spectroscopic investigation of gas-phase serotonin cooled in a supersonic expansion. UV-UV hole-burning spectroscopy was used to prove that there are five distinct conformations split into two sets separated by 230 \wn, the same spacing observed in previous work between {\it{cis}} and {\it{trans}} isomers of 5-hydroxyindole. Infrared spectra of these five conformations in the C-H, indole N-H, and O-H stretch fundamental region will be compared with those in its close analogs tryptamine and 5-hydroxyindole to determine conformational assignments for the isomers of serotonin.
Description
Author Institution: Department of Chemistry, Purdue University, West Lafayette, IN 47907