Behavior and Adherence to Black Raspberry Functional Confections Used in Oral Health Promotion

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Date

2016-05

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The Ohio State University

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Abstract

Historically, dental health research has been largely isolated from overall health research. However, in recent years, the role of good dental health as part of an overall healthy lifestyle has become more prominent. Black raspberries (BRB) contain key bioactive and health- benefitting compounds (ellagitanins and anthocyanins)associated with oral health promotion. This study analyzed data obtained from a human clinical trial conducted at the Ohio State University, in which 60 healthy adults (30 men and 30 women) consumed one of three amorphous black raspberry confections every day for two weeks at 2 different BRB doses (4g and 8g). We hypothesized that subjects participating in this study with poor diet and poor dental hygiene practices would also have poor adherence to the confection intervention. Additionally, we hypothesized that the confection matrix with the longest exposure in the oral cavity would yield the greatest concentration of total urolithins (metabolites of ellagitanins) excreted in the urine. The objectives of this research were to correlate lifestyle and modifiable behaviors with adherence to the dietary intervention and to determine difference in BRB exposure among the three BRB confections. We examined health and lifestyle questionnaires, adherence data, and quantifying total urolithin levels by HPLC MS in 24 hr. urine samples obtained from the 60 participants in the oral health promotion study. No correlation could be made between modifiable behaviors and compliance to the diet intervention. From the three confection matrices tested in this trial, the high dose (8g BRB/ piece) hard candy yielded the highest amount of urolithins in participant urine (4,695±9161 nmol/24 hr.). This work is important in identifying the optimal delivery vehicle of BRB for future clinical trials.

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1st place prize in College of Food, Agricultural, and Environmental Sciences undergraduate reserach competition

Keywords

Black raspberry, confections, oral health, functional foods, compliance

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