Cutaneous manipulation with topical solenopsin formulations of the KC-Tie2 murine model of psoriasis
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Date
2016-05
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The Ohio State University
Abstract
Psoriasis is a multifaceted disorder known to primarily affect keratinocytes, blood vessels, and the immune system. The CD1 KC-Tie2 murine model manifests symptoms analogous to those experienced by those 125 million psoriasis patients worldwide. In order to investigate the underlying causes a topical treatment, solenopsin, was applied to the psoriasiform model. After four weeks, decrease in epidermal thickness was noted. Additionally, CD4+ T cells, CD8+ T cells, and CD11c+ dendritic cells numbers were significantly reduced. Measurements of hallmark mRNA transcripts further demonstrate to reduction of T cell numbers and their downstream products. The data collected suggest control of the T‐helper17 pathway, via application of topical solenopsin, reinstates the wild type phenotype for the KC‐Tie2 model.
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Keywords
psoriasis, topical treatment, solenopsin, murine model