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Amyloidosis causes pathology through the accumulation of misfolded amyloid A protein in visceral organs, often leading to death of the animal. The increase of amyloidosis in captive cheetahs is of grave concern for the species, yet nothing is definitively known about its mechanism of transmission. One hypothesis is that amyloidosis is transmissible. Cheetah demographic and disease data were analyzed to determine the likelihood that amyloidosis is infectious. While our analysis does not disprove the infectious transmission route, simple transmission is not supported based on our findings.