THE EFFECT OF MOLECULAR INTERACTIONS ON NMR REFERENCE COMPOUNDS

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1959

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Ohio State University

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A study has been made of the effect of molecular interactions on the proton magnetic resonance (PMR) frequencies of cyclohexane and tetramethylsilane, two compounds that are frequently used as internal references for PMR investigations. In most of the cases studied the resonance frequencies of these compounds shifted 1-4 cps (at 40 mcps) when the composition of solutions containing the compounds was varied over a wide concentration range. The Presence of hydrogen bonding molecules did not cause appreciably larger interaction effects than were found for hydro-carbon-$CCl_{4}$ solutions, but benzene at high concentration caused interaction shifts of 15-17 cps.

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Author Institution: National Institutes of Health

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