Design and Instrumentation of a Multi-Modal Imaging System for Breast Cancer Detection
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Date
2008-12
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Publisher
The Ohio State University
Abstract
Breast cancer is the leading newly diagnosed cancer among women in the United States and the second leading cause of cancer deaths. This makes accurate and early diagnosis a priority. However there is controversy and problems with current diagnostic techniques such as a lack of functional measurements from Mammograms and MRI’s. Due to these limitations new techniques that overcome these problems such as combined Near Infra-red Ultrasound systems are desired. In this research an integrated dynamic Near Infra-red Ultrasound probe was developed to validate the ability of the system to produce accurate co-registered results. A second generation device was developed to use in a clinical trial that overcame the limitations of the benchtop probe. The benchtop probe produced accurate absorption properties of an embedded tissue simulating phantom. It was also proved that a user could be trained to follow within an accuracy of plus or minus 5% a computer generated pressure profile. These validation tests allowed for the system properties to be optimized prior to the current clinical trial. Future work will include implementing a contrast agent that is sensitive to both Near-Infra red and Ultrasound for better functional and structural measurements. The system could also be integrated with current cancer technology such as RF ablation to measure margins pre-operatively, intra-operatively, and post-operatively.
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Keywords
Near-Infrared, Ultrasound, Dynamic Stimuli, Absorption Coefficient, Scattering Coefficient, Force Sensing Resistor