Mycobacterium Bovis (Strain BCG) Effects on the Growth and Metastasis of a Transplantable Hamster Lung Adenocarcinoma

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1979-05

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Abstract

The effect of Bacillus-Calmette-Guerin (BCG) on the growth of an adenocarcinoma of the lung induced in a Syrian hamster was evaluated. It inhibited intradermal growth of the tumor when the tumor cells were mixed with high doses of BCG prior to intradermal injection. The development of lung metastasis after excision of the primary intradermal tumor was inhibited by BCG at doses 100 times lower than those used to inhibit the growth of intradermal tumors. The results suggest that effective immunotherapy may depend on the number of viable BCG cells, the route of administration, and the anatomic location of the tumor.

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Author Institution: Department of Microbiology, and Comprehensive Cancer Center, The Ohio State University

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The Ohio Journal of Science. v79, n3 (May, 1979), 126-130