Hydrostatic Pressure Induces Glioblastoma Cell Death in Tumor Edema Model
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Date
2017-03
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Abstract
Glioblastoma is a highly lethal brain tumor that leaves patients with a median 14 month survival time. The gold standard for patients is surgery, followed by radiation and chemotherapy, yet patient outlook is dismal. Thus, there is a critical need for new drug targets in order to improve patient outcomes. Physical forces in the tumor microenvironment represent an innovative source of drug targets, and here we have chosen to focus on interstitial fluid pressure (IFP). IFP is the result of angiogenesis and new leaky blood vessels. In our in vitro model, we simulate this IFP and find that tumor cells experience the most cell death at an IFP within the range of a normal healthy adult. Further, this cell death is apoptotic and p-Akt and beta-1 integrin are implicated in this cell death mechanism. These data help to move the field of mechanobiology forward, and begin to pave the way towards the development of a new drug that works in conjunction with a physical force in the tumor microenvironment to destroy tumor cells.
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Engineering: 2nd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)
Keywords
Interstitial Fluid Pressure, Glioblastoma, Cancer, Cell Death