Effects of risperidone on cognitive-motor performance and motor movements in chronically medicated children
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Date
2009
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Ltd.
Abstract
This study was designed to explore the placebo-controlled effects of risperidone on cognitive-motor
processes, dyskinetic movements, and behavior in children receiving maintenance risperidone therapy.
Sixteen children aged 4-14 years with disruptive behavior were randomly assigned to drug order in a
crossover study of risperidone and placebo for 2 weeks each. Dependent measures included tests of sustained
attention, memory, visual matching, tremor, seat activity, abnormal movements, and parent behavior ratings.
Results were compared by repeated measures ANOVA Fourteen boys and 2 girls with disruptive behavior
and IQ ≤ 84 all completed the protocol. Risperidone was superior to placebo on response time (p = 0.01, ηP ^
2 =
0.43) and seat movement (p < 0.05, ηP ^
2 = 0.29) on a short-term memory task, and on a measure of static tremor
(p = 0.05, ηP ^
2 = 0.28). There was not a significant difference between treatment conditions on the Abnormal
Involuntary Movement scale. Risperidone was superior to placebo on three subscales of the Nisonger Child
Behavior Rating Form [Overly Sensitive (p < 0.01, ηP ^
2 = 0.44), Conduct Problem (p = 0.02, ηP ^
2 = 0.36),
Hyperactivity (p = 0.03, ηP ^
2 = 0.32)] and on the Hyperactivity/Noncompliance subscale of the Aberrant
Behavior Checklist (p = 0.01, ηP ^
2 = 0.41). Significant increases in heart rate (p = 0.05, ηP ^
2 = 0.27) and weight (p
= 0.02, ηP ^
2 = 0.36) occurred in the risperidone condition. The findings suggest a beneficial effect of
risperidone after several months of treatment on efficiency of responding, activity level, static tremor, and
aspects of behavior.
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Citation
Michael G. Aman et al, "Effects of risperidone on cognitive-motor performance and motor movements in chronically medicated children," Research in Developmental Disabilities 30, no. 2 (2009), doi:10.1016/j.ridd.2008.07.004