SPECTROSCOPIC STUDIES OF SOME NEW SYNTHESIZED 2(1$H$)-PYRIDINONES AND THEIR NUCLEOSIDES AS POTENTIAL PROBES FOR MONITORING CELL PROLIFERATION AND APOPTOSIS IN HUMAN LEUKEMIA HL-60 CELLS
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Date
2007
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Publisher
Ohio State University
Abstract
New series of substituted 2(1$H$)-pyridinones \textbf{(1a-e)} and their nucleosides \textbf{(3a-e)} were prepared as potential agents against leukemia. The nucleosides \textbf{(2a-e)} were synthesized using two independent methods and their structures were confirmed using FT-IR, 1D, and 2D-NMR techniques. 3-Cyano-4-(thien-2$^\prime$-yl)-6-(4$^{\prime\prime}$-chlorophenyl)-2(1$H$)-pyridinone \textbf{(1e)} and its nucleoside (\textbf{2e} and \textbf{3e}) were found to have the highest activity against proliferation of the human promyelotic leukemia (HL-60) cells. Pyridinone derivatives substituted at position 4 with a 2-thienyl or 2-(trifluoromethyl)phenyl groups were found to exhibit high potency against apoptosis.
Description
Author Institution: Department of Chemistry, Faculty of Science, UAE University,; Al-Ain P.O. Box 17551 UAE; Department of Biochemistry, Faculty of Medicine \& Health Science, UAE University, Al-Ain P.O. Box 17666 UAE