SURFACE-ENHANCED RAMAN SPECTROSCOPY OF BILIRUBIN
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Date
1986
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Ohio State University
Abstract
We have investigated the surface-enhanced Raman spectroscopy of bilirubin and its albumin complexes on silver colloids. The di-carboxylate anion is the SERS active species. Adsorption on silver stabilizes the system against photodecomposition, allowing close approach to electronic resonance. Strong enhancement of in-plane ring modes suggests binding through carboxylates, with rings oriented normal to the silver surface. The intense SERS signals obtained with albumin complexes, and the small frequency differences suggest that one or both dipyrrole rings remain bound to albumin in the SERS-active molecules.
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Address of Hsieh and Morris: Department of Chemistry, University of Michigan, Ann Arbor, MI 48109.
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