Application of Reptilian Adult Neurogenesis in Mammalian Brains
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Date
2023-05
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The Ohio State University
Abstract
Adult neurogenesis, which is the development of new neurons in the brain, is a process that is only rarely seen in adult mammals but is commonly seen in a variety of adult reptiles typically after an injury. Reptiles and mammals have similar brains with several homologous areas, so the study of reptilian adult neurogenesis could lead to the discovery of mammalian adult neurogenesis, particularly in the cortex and other telencephalic divisions. Due to the many documented cases of reptilian adult neurogenesis, a thorough review of the literature is necessary to design a study that would involve the use of reptilian models to identify any gene(s) causing adult neurogenesis to occur and then identifying a homologous adaptation in mammalian models. From there, studying that adaptation to see what might turn on adult neurogenesis in mammals. Finally, this information could help develop new treatments for illnesses and injuries that would cause the loss of functioning brain tissue in mammals, such as Alzheimer's disease and rabies.
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Keywords
Adult neurogenesis, Neurogenesis, Reptiles, Mammals