Functionalization of Polycaprolactone via Aminolysis for Optimal Oxygen Sensor Biodegradability
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Date
2020-12
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The Ohio State University
Abstract
A primary amine was utilized to react with and chemically modify a specific polyester, polycaprolactone (PCL), enabling biomedical sensing functions along with additional biological utility. PCL is a good substrate for reaction chemistry exploration as it has a role in a range of biomedical applications due to its relatively slow biodegradability. While PCL modifications have been undertaken previously using a variety of approaches, much of the resulting evaluation is based on performance in the application, rather than definitive confirmation that chemical attachment has truly taken place. True verification of these chemical modifications is absent from the literature. The work described here addresses this central challenge addressed here via the use of HMBC NMR combined with XPS and UV-VIS analysis.