Vascular Development in the Hippocampal Neurogenic Niche
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Date
2022-05
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Publisher
The Ohio State University
Abstract
Adult neurogenesis occurs in microenvironments called stem cell niches, one of which is the subgranular zone (SGZ) of the dentate gyrus (DG) in the hippocampus. The hippocampal neurogenic niche also has a unique vascular structure, with different regions of the DG having varying vascular coverage. Though it is known that this vascular pattern exists, little is known about how it arises during development. Here, I show that the unique vascular pattern of the hippocampal neurogenic niche is not fully developed until adulthood in wild-type mice. By measuring vascular area in DG subregions from juvenile to adult ages, I found that the vascular coverage of the molecular layer and hilus (HL) of the DG decreases over development while the vascular coverage of the SGZ and the granular cell layer (GCL) remain constant. These changes resulting in the SGZ being a more vascularized niche compared to its neighboring HL and GCL were not complete until 9 weeks of age. Further, the neural stem and progenitor cells found in the SGZ show preferential association with vasculature, and the magnitude of association remains constant over development.
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Keywords
Hippocampus, Vasculature, Development, Mouse