Controlled Phenylhydrazine-Induced Reticulocytosis in the Rat
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Date
1970-09
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Abstract
The pattern of development of phenylhydrazine-induced rat reticulocytosis was studied over a period of nine days. Intraperitoneal injections of phenylhydrazine (4 mg/100 gm) every other day caused a fall in hematocrit which leveled off at 60% of normal by the fifth day. Increased erythropoiesis was indicated by a three-fold increase in the number of circulating reituclocytes after the first three injections. The immediate response was the release of stored mature reticulocytes from the bone marrow. As the anemia progressed, more and more young reticulocytes appeared until 70 to 85% of the red cells in the peripheral circulation were reticulocytes and 20% of these were juvenile forms.
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Author Institution: Department of Physiology, Ohio State University, College of Medicine, Columbus, Ohio 43210
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Citation
The Ohio Journal of Science. v70 n5 (September, 1970), 300-304