Sow milk composition changes over lactation, and modulation of maternal diet may enhance intestinal epithelial cell membrane composition to enhance gut barrier function in the suckling neonatal piglet
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Date
2019-05
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The Ohio State University
Abstract
Dietary nutrients are essential for gastrointestinal (GI) growth and function, and a significant component of neonatal development requires the nutritional support of GI growth and development. Nutritional provisions of the mother's milk support normal maturation of structure and function of the GI tract in most neonates. The composition of mother's milk affects GI, mucosal immune system, and neurological development. The functional nutrients and other bioactive components of milk support a microenvironment for gut protection and maturation. However, early intestinal maladies can impair normal GI development, leading to intestinal dysfunction and even death. Therefore, our study evaluated sow colostrum and milk composition of the bioactive phospholipids of the milk fat globule membrane, as well as, milk protein composition to gain knowledge about potential ways to modulate maternal diet to enhance gut barrier function of suckling piglets, a dual purpose agri-medical model. Experiment one collected colostrum and mature milk from 11 first parity sows at 12-24h and 8-10d post-partum, respectively. The percent total solids were significantly greater in colostrum samples compared to mature milk samples (23.51 vs. 19.29 ±1.34; P<0.05), however total fat was not significantly different between sow colostrum and mature milk (8.93 vs. 8.33 ± 0.78; P>0.05). Total phospholipids and milk associated proteins were also greater in colostrum vs. milk. Interest in suckling neonatal piglet intestinal phospholipid composition derive from maternal diet led to the development of a piglet intestinal cell culture model to determine if we could enrichment of LC-PUFA in the cell membrane for developing an in vitro challenge model. In conclusion, we know milk composition changes over lactation and changes in milk solids, specifically phospholipids, may play an important role in modulation of intestinal health in neonates.
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3rd Place in the Nutrition Category of the CFAES 2018 Undergraduate Research Forum
Keywords
Swine nutrition, gut health, milk composition, neonatal health