VIBRATIONAL CIRCULAR DICHROISM OF SMALL PEPTIDES AND PEPTIDE MODELS IN SOLUTIONS: EXPERIMENTAL DATA AND CALCULATIONS

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1988

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Ohio State University

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We have observed VCD in the amide I, II and III region of peptides in aqueous solution (1250−1750cm−1), and for certain amino acids down to 900cm−1 in heavy water. VCD of peptide models was obtained from solutions in aqueous as well as organic media. Strong coupling of amide I vibrations was observed even in very small peptides in solution. This coupling is interpreted in terms of a stable solution conformer. The coupled oscillator formalism is used to deduce the angles between the interacting transitions.

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Author Institution: Department of Chemistry, City University of New York. Hunter College

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http://hdl.handle.net/1811/17464

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Abstracts of OSU International Symposium on Molecular Spectroscopy 1980-1989