VIBRATIONAL CIRCULAR DICHROISM OF SMALL PEPTIDES AND PEPTIDE MODELS IN SOLUTIONS: EXPERIMENTAL DATA AND CALCULATIONS
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Date
1988
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Ohio State University
Abstract
We have observed VCD in the amide I, II and III region of peptides in aqueous solution $(1250 - 1750 cm^{-1})$, and for certain amino acids down to $900 cm^{-1}$ in heavy water. VCD of peptide models was obtained from solutions in aqueous as well as organic media. Strong coupling of amide I vibrations was observed even in very small peptides in solution. This coupling is interpreted in terms of a stable solution conformer. The coupled oscillator formalism is used to deduce the angles between the interacting transitions.
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Author Institution: Department of Chemistry, City University of New York. Hunter College