Synthesis and stability of boron cage derivatives for use as cancer targeting agents
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Date
2010-06
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The Ohio State University
Abstract
The focus of this research has been to investigate whether a boron cage derivative composed of iodine would be a thermodynamically stable compound that could be incorporated into monoclonal antibodies. These monoclonal antibodies would be used to diagnose and treat breast cancer. First, Cs2[B10I10] was successfully synthesized. In future studies, this compound will be mixed with rate plasma and peroxidase as a way to test its stability in physiologic conditions. Second, multiple attempts were made to synthesize [NH(Et)3][NMe4][B10H9NCS]. This is a boron compound with a linking component, isothiocyanate. Having a linking component would allow the boron compound to attach to the antibody. Unfortunately, it is not certain that [NH(Et)3][NMe4][B10H9NCS] was synthesized. Rather, it is believed a mixture of products with the key components: isothiocyanate and a boron cage were created. Future research will continue to synthesize this product and eventually attach iodine to the boron cage. All products synthesized were verified with 1H NMR, 13C NMR, 11B NMR, and Infrared Spectroscopy.
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Keywords
boron cages attached to monoclonal antibodies, boron cages with isothiocyanate