VIBRATIONAL CIRCULAR DICHROISM OF AMINO ACIDS AND OLIGOPEPTIDES AS A FUNCTION OF SOLUTION pH

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1986

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Ohio State University

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VCD spectra in the C-H stretching and C-H bending regions for selected amino acids, dipeptides, and tripeptides at various pH values will be presented. The changes observed in the VCD of these small biological molecules in aqueous solution as a function of pH support the recently proposed ring current mechanism of VCD. It is proposed that electronically generated ring current loops closed by intramolecular hydrogen bonding within many types of molecules results in enhanced VCD intensities. The alteration of the pH of solutions of amino acids and small peptides apparently disrupts this intramolecular hydrogen bonding. Further evidence of the ring current mechanism will be demonstrated through examination of these effects.

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Address: Department of Chemistry, Syracuse University, Syracuse, New York 13244.
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http://hdl.handle.net/1811/16984

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Abstracts of OSU International Symposium on Molecular Spectroscopy 1980-1989