Examination of differences in added sugar consumption and urinary sugar excretion between post-menopausal women with healthy weight and post-menopausal women with obesity

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2018-12

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The Ohio State University

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Accurate records of added sugar (AS) intake are difficult to keep. Valid and reliable biomarkers of added sugar consumption are needed to study its relationship to disease. This project is an examination of differences in AS consumption and urinary excretion in post-menopausal women with healthy weight and post-menopausal women with obesity. Healthy, postmenopausal women were recruited from the Franklin County area; 15 lean (BMI 18.5-24.9 kg/m2) and 15 obese (BMI ≥30 kg/m2) women were enrolled. This study used a pre-post test, single group design. An initial visit was conducted to determine eligibility, obtain informed consent and collect anthropometric, demographic, and lifestyle data. Participants completed two separate 24-hour food records of usual dietary intake followed by fasting morning urine collections. Record collection days were one week apart, and a sugar-sweetened beverage was added to usual intake on the second day. The Nutrition Data System for Research (NDSR) was used to analyze food records. Urinary sucrose excretion was analyzed using a modified enzymatic assay.The mean body mass index (BMI) of the study participants was 30.7±8.0 and an average age of 60 years old ±5 years. Women with normal weight consumed more AS, (88±48gm, p=<0.01), on day 2. Women with obesity also consumed more AS (83±40g, p=<0.01) on day 2 Urine analyses indicate that on study day 2, there was three times the amount of sucrose detected in the urine of the women with normal weight than in the women with obesity (p=0.043). When consuming a sugar-sweetened beverage, urinary sucrose excretion is detectable among women with normal weight.

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Added Sugar, Post-Menopausal Women, Dietary Food Record, Sugar Sweetened Beverage, Urinary Sucrose Excretion

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http://hdl.handle.net/1811/86897

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Education and Human Ecology Undergraduate Research Theses and Honors Research Theses