Characterization of Trans-membrane Apparatuses in the Gram Negative Opportunistic Pathogens Nontypeable Haemophilus influenzae and Acinetobacter baumannii
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Date
2012-12
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The Ohio State University
Abstract
In today’s world of ever evolving pathogens and rapidly acquired antibiotic resistance, the characterization of virulence factors has become increasingly important. Elucidating the mechanisms of action of these factors allows not only for a fundamental understanding of how microorganisms cause disease but also the identification of putative vaccine candidates. This work focuses primarily on trans-envelope molecular machinery in Gram-negative opportunistic pathogens, specifically, the type IV pili of nontypeable Haemophilus influenzae (NTHi) and the type VI secretion system of Acinetobacter baumannii. Each system mediates a variety of cellular processes and may be involved in the progression of disease in humans; therefore each is of great interest to the wellbeing of society. Here, we describe the characterization of components of NTHi type IV pili and A. baumannii type VI secretion in order to gain further insight into their biogenesis and function.
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Keywords
Nontypeable Haemophilus influenzae, Acinetobacter baumannii, Type VI Secretion System, Type IV Pili