Evaluation of Brain Cancer Cell Migration Using Three-dimension Brain Mimetic Hydrogels
Loading...
Date
2018-03
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Approximately 22,500 new cases of brain cancer are diagnosed in the United State every year. Glioblastoma (GB) is the most lethal form of brain cancer with a minimal patient survival time~15 months. Unlike other types of cancer, GB rarely metastasizes to other organs but instead diffuses to tissues surrounding the tumor site making it hard to define the tumor region. This invasive nature of GB has caused great challenges in clinical treatments. The current standard of care for GB patients is surgical removal of the tumor mass followed by radiation and/or chemotherapy. However, it’s almost impossible to remove the tumor completely due to the unclear tumor edge. GB cells have also demonstrated resistance to radio- and chemotherapies—in some cases, radiation treatments may even increase the migration ability of the tumor cells. Therefore, strategies targeting cell migration has been tested in clinical trials as an addition to the standard but few success has been made. The purpose of this study was to evaluate GB cell migration in a true three-dimension (3D) environment which mimics the brain tissue and better captures cell behavior than conventional 2D cultures. We particularly studied the effects of different inhibition methods on GB migration which offered future directions in brain cancer treatment.
Description
Engineering: 1st Place (The Ohio State University Edward F. Hayes Graduate Research Forum)
Keywords
Glioblastoma, Hydrogel, Hyaluronic acid, Cell migration