The Molecular Mechanisms of Testosterone Depletion during Skeletal Myogenesis
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Date
2015-05
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Publisher
The Ohio State University
Abstract
The study presented here provided a vast array of data that provides a thorough basis for further studies to be designed. The regulators of differentiation have been identified and qualitatively correlated with their proposed function in regards to testosterone depletion, and a possible biomarker for testosterone status has been identified in HSP90. The basis set of data, which is comprised of proteomic, transcriptional, and pathway analyses, provides a multitude of future directions, and the molecular mechanisms of testosterone depletion are being unraveled, and will continue to be determined in the near future.
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Keywords
Testosterone, muscle cells, myogenesis, depletion, proteomics