Social Stress Causes Extramedullary Hematopoiesis in the Spleen
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Date
2016-02
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Abstract
Chronic psychological stress promotes hematopoietic production of proinflammatory innate myeloid cells, such as monocytes and neutrophils. Enhanced production of proinflammatory myeloid cells is tightly linked to negative health outcomes in both high stress populations. Circumstances with leukocyte demand (e.g., infection, cancer, blood loss) hematopoiesis may occur outside of the bone marrow, such as within the spleen. Mechanisms of enhanced myelopoiesis with stress are explored here in a mouse model of psychosocial stress. In vitro colony forming unit (CFU) assays were performed on bone marrow, blood, and spleen following six cycles of repeated social defeat (RSD) stress. RSD increased colony forming units in the blood and spleen but not the bone marrow. However, the phenotype of CFU in the bone marrow was shifted from erythropoietic to myelopoietic progenitors. Taken together these results show that RSD skewed bone marrow hematopoiesis towards myelopoiesis, and that RSD increased extramedullary hematopoiesis in the spleen. For the first time, this study demonstrates that social stress promotes extramedullary hematopoiesis as a novel mechanism of stress-induced myelopoiesis.
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Professional Biological Sciences: 1st Place (The Ohio State University Edward F. Hayes Graduate Research Forum)
Keywords
Stress, Hematopoiesis