Identification of Compounds that Modulate Ependymal Cell Cilia Beat Frequency

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2025-02-19

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Ependymal cells line the ventricles within the brain and contain motile cilia. The beating of these cilia contribute to near wall flow networks of the cerebrospinal fluid. The cerebrospinal flow networks have been shown to have altered flow patterns under different conditions. These flow networks could be involved in the pathology and physiology of conditions such as hydrocephalus, mood disorders, and traumatic brain injury. Which has led our lab to hypothesize that ependymal cell cilia are sensory organelles that respond to their environment. This project specifically looks at how adenosine and temperature modulate the beat frequency of the ependymal cilia.

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STEP Category: Undergraduate Research

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