Development of tools for the analysis of DNA double strand break repair
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Publisher:The Ohio State University
Series/Report no.:The Ohio State University. Department of Molecular Genetics Undergraduate Research Theses; 2019
Repair of DNA double strand breaks are very important in molecular biology. They play a role in the stability of a genome, and if not repaired quickly and correctly can lead to serious problems for the cell. These problems include genomic instability, chromosomal deletions, duplications, and inversions to name a few. Incorrect repair of these breaks leads to accumulation of DNA damage, so it is important to understand the mechanisms by which these breaks occur and are repaired. Development of new molecular methods is critical to helping researchers determine mechanisms of repair. Here I outline several assays that we have designed for the analysis of in vivo DNA double strand break repair.
Academic Major: Biology
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