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dc.contributor.advisorLee, Nam
dc.creatorElmasry, Fatema
dc.creatorWheeler, Sarah
dc.creatorPan, Chris
dc.creatorKumar, Sanjay
dc.creatorZaman, Naveed
dc.creatorShah, Nirav
dc.creatorTran, Alex
dc.date.accessioned2016-09-30T22:03:00Z
dc.date.available2016-09-30T22:03:00Z
dc.date.issued2016-09-15
dc.identifier.urihttp://hdl.handle.net/1811/78515
dc.descriptionBiological and Biomedical Sciencesen_US
dc.description.abstractAngiogenesis is the formation of new blood vessels from preexisting vasculature, an essential process during development and tumor growth. Endoglin is a TGF-β co-receptor expressed predominantly in proliferating endothelial cells required for angiogenesis. Recently, our lab discovered an unexpected novel cross-talk between insulin and TGF-β signaling pathways. The purpose of this study was to examine the role of endoglin in insulin-mediated Smad signaling. Immunofluorescence and biochemical methods were used to assess cellular changes in Smad1/5/8 activation (pro-angiogenic). Preliminary data indicates that endoglin expression is required for insulin induced Smad1/5/8 activation. Given that type 2 diabetic patients are susceptible to a number of vascular-related conditions and malignancies, our results reveal new pathophysiologic implications for Smad1/5/8 signaling through hyperinsulinemia during pre-diabetic and diabetic disease progression.en_US
dc.language.isoenen_US
dc.relation.ispartofseries2016 Fall Undergraduate Research Student Poster Forum. 10then_US
dc.subjectAngiogenesisen_US
dc.subjectInsulinen_US
dc.subjectEndoglinen_US
dc.subjectEndothelial Cellsen_US
dc.titleThe Role of Endoglin in Insulin-Mediated Angiogenesisen_US
dc.typePresentationen_US
dc.type.genrePosteren_US
dc.description.academicmajorAcademic Major: Pharmaceutical Sciencesen_US


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