Show simple item record

dc.contributor.advisorLee, Nam
dc.creatorElmasry, Fatema
dc.creatorWheeler, Sarah
dc.creatorPan, Chris
dc.creatorKumar, Sanjay
dc.creatorZaman, Naveed
dc.creatorShah, Nirav
dc.creatorTran, Alex
dc.descriptionBiological and Biomedical Sciencesen_US
dc.description.abstractAngiogenesis is the formation of new blood vessels from preexisting vasculature, an essential process during development and tumor growth. Endoglin is a TGF-β co-receptor expressed predominantly in proliferating endothelial cells required for angiogenesis. Recently, our lab discovered an unexpected novel cross-talk between insulin and TGF-β signaling pathways. The purpose of this study was to examine the role of endoglin in insulin-mediated Smad signaling. Immunofluorescence and biochemical methods were used to assess cellular changes in Smad1/5/8 activation (pro-angiogenic). Preliminary data indicates that endoglin expression is required for insulin induced Smad1/5/8 activation. Given that type 2 diabetic patients are susceptible to a number of vascular-related conditions and malignancies, our results reveal new pathophysiologic implications for Smad1/5/8 signaling through hyperinsulinemia during pre-diabetic and diabetic disease progression.en_US
dc.relation.ispartofseries2016 Fall Undergraduate Research Student Poster Forum. 10then_US
dc.subjectEndothelial Cellsen_US
dc.titleThe Role of Endoglin in Insulin-Mediated Angiogenesisen_US
dc.description.academicmajorAcademic Major: Pharmaceutical Sciencesen_US

Files in this item


Items in Knowledge Bank are protected by copyright, with all rights reserved, unless otherwise indicated.

This item appears in the following Collection(s)

Show simple item record