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dc.contributor.advisorHabing, Gregory
dc.creatorHutchinson, Holden
dc.date.accessioned2016-04-17T19:06:20Z
dc.date.available2016-04-17T19:06:20Z
dc.date.issued2016-05
dc.identifier.urihttp://hdl.handle.net/1811/76499
dc.description.abstractAntimicrobial resistance is a public health concern for both human and veterinary medicine. In food animal production systems, medically important antimicrobials are used for both prophylactic and therapeutic purposes; therefore, food animals have the potential to serve as a reservoir for antimicrobial resistant bacteria. Previous research has shown an uneven distribution of resistance with a higher prevalence within young animals; however, limited research has addressed antimicrobial resistance within veal production systems. Vertically integrated veal production systems provide a unique opportunity to study the transmission of resistance through the food supply. The study’s objective was to estimate the prevalence of antimicrobial resistant Escherichia coli within different stages of a vertically integrated veal production system. A total of 377 fecal samples were collected from nine different calf cohorts on six farms, where the average age was 69 days (range: 8-115). Four of these cohorts were followed to harvest for additional sample collection. At harvest, a total of 159 fecal samples, 161 pre-evisceration and 150 post-evisceration carcass swabs were collected. A single E. coli isolate from the samples was subjected to twelve antimicrobials using Kirby-Bauer disk diffusion assays. Zones of growth inhibition were measured for each antimicrobial and classified as resistant or susceptible based on CLSI interpretive criteria. E. coli Isolates were obtained from 100% of fecal samples, 52% (84/161) of pre-evisceration swabs and 16% (24/150) of post-evisceration swabs. Greater than 98% (372/377) of isolates obtained from farm fecal samples were resistant to two or more classes of antimicrobials. A decrease in resistance was seen at harvest where only 46.9% (73/159), 69.0% (58/84), and 29.2% (7/24) of isolates from fecal samples, pre-evisceration and post-evisceration carcass swabs, were resistant to two or more antimicrobials. These results provide insight to the current prevalence of resistance among the production system and the opportunity for further research to determine factors affecting the prevalence of resistance.en_US
dc.language.isoen_USen_US
dc.publisherThe Ohio State Universityen_US
dc.relation.ispartofseriesThe Ohio State University. Department of Animal Sciences Honors Theses; 2016en_US
dc.subjectantimicrobialen_US
dc.subjectresistanceen_US
dc.subjectvealen_US
dc.subjectprophylacticen_US
dc.titleChanges in the Prevalence of Antimicrobial Resistance in a Vertically Integrated Veal Calf Production Systemen_US
dc.typeThesisen_US
dc.description.embargoNo embargoen_US
dc.description.academicmajorAcademic Major: Animal Sciencesen_US


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