Effects of Estrogen on Aggressive Behavior
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Publisher:The Ohio State University
Series/Report no.:The Ohio State University. Department of Psychology Honors Theses; 2006
Estrogens are known modulators of aggression however, the specific action of estrogens on brain function has not been determined. In a correlational study, the number of estrogen receptors in regions of the hypothalamus and limbic system was correlated with aggressive behavior in a domestic strain of mice (CD-1). To determine whether these correlations reflect the effect of estrogen on aggression, the production of estrogen was manipulated by an aromatase inhibitor (fadrozole) to observe the subsequent effects on aggressive behavior. Reduction of estrogen production resulted in a decrease in aggressive behavior, suggesting that estrogen acts to increase aggression.
Denman Undergraduate Research Forum Psychology Division First Place
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