Expression of DDR1 and DDR2 in Peripheral Blood
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Publisher:The Ohio State University
Series/Report no.:The Ohio State University. Department of Biomedical Engineering Honors Theses; 2014
Interactions between blood cells and collagen play a critical role in inflammation, and are implicated in various vascular diseases. Specifically, platelet-collagen adhesion initiates the clotting cascade, which can lead to thrombus formation and eventual myocardial infarction. However, modulation of platelet adhesion by altering the native structure of collagen remains relatively unexplored. Discoidin domain receptors (DDRs) are a unique family of collagen-binding receptors that are activated by their ligand collagen, and play an important role in collagen remodeling. This study aims to determine expression of DDRs on leukocyte and platelet blood fractions, with the long term goal of identifying the pathogenic mechanisms of cell-collagen interactions.
Academic Major: Biomedical Engineering
The College of Engineering
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