Waveguide Magnetic Resonance Elastography in a Pressure-Varying Porcine Model
Keywords:Anisotropic myocardial stiffness (AMS)
Diffusion tensor imaging (DTI).
Waveguide cardiac magnetic resonance elastography (CMRE)
Isotropic myocardial stiffness (IMS)
Magnetic Resonance Imaging (MRI)
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Series/Report no.:2014 Edward F. Hayes Graduate Research Forum. 28th
Purpose: To determine anisotropic myocardial stiffness using waveguide cardiac magnetic resonance elastography (CMRE) in an ex-vivo porcine model with varying left ventricular pressure simulating heart failure with preserved ejection fraction and compare the results against isotropic myocardial stiffness. Methods: Diffusion tensor imaging (DTI) and CMRE was implemented on three ex-vivo porcine hearts inflated with two different pressure values on a 3T MRI scanner to obtain fiber orientation and displacement information respectively. An orthotropic inversion was performed on the displacement data to estimate the anisotropic stiffness coefficients (compressional and shear) in the heart for both the inflation pressures and the results were compared against isotropic stiffness estimates. Paired student’s t-test was performed to determine the significant difference in stiffness values between the two inflation pressures with the two different inversion techniques. Results: Our results show that anisotropic stiffness estimates demonstrated a significant difference between the two inflation pressures both in the compressional (P-Value=0.0053) and shear (P-Value=0.0015) measurements. On the other hand, the isotopic stiffness measurements showed a minute slight increase in stiffness as a function of pressure with no significant difference (P-value=0.75). Conclusion: From the results we can conclude that it is feasible to estimate anisotropic stiffness in the myocardium and anisotropic myocardial stiffness provides superior information as compared to isotropic myocardial stiffness.
Engineering: 3rd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)
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