Transcriptomic evidence for dramatic functional transition of the Malpighian Tubules after a blood meal in the Asian tiger mosquito Aedes albopictus
Advisor:Piermarini, Peter M
Contributors:Cassone, Bryan J.
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Series/Report no.:Entomology. Graduate student poster competition, 2014
Vector-borne diseases transmitted by mosquitoes are important for global health, because cause hundreds of thousands of deaths and sickening hundreds of millions people each year. The Asian tiger mosquito (Aedes albopictus), is enhancing this risk in the world and the United States. Ae. albopictus is vector of diseases such as West Nile fever, dengue fever, chikungunya fever, and Eastern Equine Encephalitis. To date, this research has used single-end RNA-Seq to demonstrate that a blood meal affects the expression of more than 1800 non-redundant transcripts and 15 metabolic pathways in Malpighian tubules of the Asian tiger mosquito, in a manner that suggests a potential functional transition in the epithelium from one dedicated to salt and water excretion to one dedicated to the metabolism and excretion of metabolites derived from a blood meal.
Financial support for these studies is provided by OARDC SEEDS Grant OHOA1471.