Collagen microstructure basis for the correlation between acoustic and biomechanical properties of the cornea
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Publisher:The Ohio State University
Series/Report no.:The Ohio State University. Department of Biomedical Engineering Honors Theses; 2014
Biomechanical properties of the tissue comprising the eye, including the cornea and sclera, are important for the function of the eye. Knowing the mechanical properties of the eye will help develop and improve vision technology and treatments. The noninvasive assessment of in vivo mechanical properties is a challenge in the fields of biomechanics and ophthalmology due to a current lack of available and accurate technology. Recent findings indicate that acoustic impedance and the Young’s modulus of the cornea are strongly correlated. However, the mechanisms responsible for this correlation remain unclear. This may result from the microstructure, which includes the type and arrangement of collagen fibers. In this study, fresh canine corneas were dissected and acoustically and mechanically tested through amplitude-mode ultrasound and strain-controlled rheometry, respectively. The tissue samples were then prepared for the collagen assay following acoustic and mechanical testing. The collagen content was assessed through a hydroxyproline collagen assay. The preliminary results showed a potential trend for correlations between acoustic properties and collagen content, but the methods will require adjustments and further investigation.
OSU Engineering Undergraduate Honors Research Scholarship
Academic Major: Biomedical Engineering
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