Vitamin supplementation effects on homocysteine and psychological functioning
Creators:Trinidad, Marcy Camilla
MetadataShow full item record
Publisher:The Ohio State University
Series/Report no.:The Ohio State University. Department of Psychology Honors Theses; 2005
Elevated homocysteine levels are associated with increased risk of heart disease. One possible strategy to reduce risk of heart disease is through reduction of homocysteine with vitamin B. Eighty middle-aged men and women participated in a four-week study examining vitamin supplementation effects. Pre-test measures consisted of the Beck Depression Inventory, Revised Life Orientation Test, Cohen’s Perceived Stress Scale, and an assessment of homocysteine. Post-test measures included the same battery of tests as well as the Profile of Mood States. Participants were randomly assigned to receive either the self-administered supplement consisting of 0.4 mg folate, 0.4 mg B12, and 10 mg B6 or a placebo. Data were analyzed with repeated measures analysis of variance with time (pre-test v. post-test) as a within-subjects factor and condition (vitamin v. placebo) as a between-subjects factor. With an alpha level of 0.05, no statistically significant effect of supplementation was found for depression, F (1, 80) = 2.27, p = 0.14 or homocysteine, F (1, 80) = 0.80, p = 0.37.
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