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dc.contributor.advisorBasso, D. Michele
dc.contributor.advisorLiu, Jun
dc.creatorBlack, Nicholas
dc.descriptionBiological Sciences: 1st Place (The Ohio State University Denman Undergraduate Research Forum)en_US
dc.description.abstractSpinal cord injury (SCI) results in a breakdown of the blood-spinal cord barrier (BSCB) that permits a robust inflammatory response. Mechanisms responsible for inflammation promote further damage to the neural tissue. Neurotoxicity results from inflammatory cells moving into the spinal cord through the damaged and permeable blood vessels. Activities such as treadmill training attempt to utilize spinal plasticity to promote recovery, but recent animal studies have shown increased BSCB permeability with early swim training [1]. Exercise-regulated gelatinase matrix metalloproteinase-9 (MMP-9) is a regulator of vascular permeability utilized to degrade tight-junctions of the blood vessel wall, allowing extravasation into surrounding tissues. MMP-9 is a potent early regulator of pathology after SCI. Whether locomotor training stabilizes or exacerbates BSCB integrity is unknown.en_US
dc.description.sponsorshipNIH grants 1RO1NS074882-01A1 and 1F31NS080512-01en_US
dc.relation.ispartofseries2013 Richard J. and Martha D. Denman Undergraduate Research Forum. 18then_US
dc.subjectspinal cord injuryen_US
dc.subjectfunctional recoveryen_US
dc.subjectevans blue dyeen_US
dc.titleEffect of Early Weight-Bearing Training on Blood-Spinal Cord Barrier Function in Miceen_US
dc.description.academicmajorAcademic Major: Biomedical Engineeringen_US

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