Identification of NF-κB Inhibitors from Watercress
Advisor:Carcache de Blanco, Esperanza
MetadataShow full item record
Publisher:The Ohio State University
Series/Report no.:The Ohio State University. Department of Pharmaceutical Sciences Honors Theses; 2013
Watercress, Nasturtium officinale W.T. Aiton, a member of the Brassicaceae family, is highly consumed in salad mixes and contains many phytochemicals. As part of the cancer chemoprevention drug discovery program, watercress was tested in a panel of bioassays. The small scale hexane extract of watercress exhibited over 65% NF-kB inhibition at a concentration of 50 µM. NF-κB is a hallmark for cancer and disregulation of NF-κB has also been linked to inflammation and auto immune diseases. Three isolated samples from the hexane extract were tested in assays for biological activity. While the large scale hexane extract of watercress did not demonstrate potent NF-κB inhibition, it was found that one of the isolated samples showed some activity in the NF-κB assay.
Related Item:Academic Major: Pharmaceutical Sciences
The Ohio State University College of Pharmacy
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