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dc.contributor.advisorKinghorn, A. Douglas
dc.creatorGromovsky, Anthony
dc.date.accessioned2013-04-16T23:01:29Z
dc.date.available2013-04-16T23:01:29Z
dc.date.issued2013-05
dc.identifier.urihttp://hdl.handle.net/1811/54560
dc.description1st Place Winner at 2013 Denman Undergraduate Research Forum (Health Sciences - Laboratory/Cellular)en_US
dc.description2nd Place Winner at the 2013 College of Pharmacy Research Day Forumen_US
dc.description.abstractLeishmaniasis is a parasitic disease with a high incidence of infection and, in some cases, the potential to be fatal. This disease is largely entrenched in poverty, making access to effective and inexpensive diagnoses, treatments, and disease control unattainable for countless infected individuals. The need for affordable, more effective, and less toxic treatments has led us to the preparation and testing of plant extracts for screening against L. donovani parasites. Fractionation of the cones of a North American plant, found on The Ohio State University (OSU) campus and identified at the herbarium of The Ohio State University Museum of Biological Diversity as Taxodium distichum Rich. (Cupressaceae), commonly termed the bald cypress, has led to the observation of in vitro and in vivo activity against L. donovani. Previous studies have shown that abietane-type diterpenes, such as taxodione, taxodone, and taxodistines A and B are the major compounds present in the cones of T. distichum. These compounds have previously been reported to have antitumor, antimicrobial, and antileishmanial activity, but unfortunately have also been found to be accompanied by serious undesired toxicity. The purpose of this study was to isolate an antileishmanial compound or compounds from this plant source, which resulted in the purification and identification of taxoquinone and sugiol. Further fractionation is being conducted for the isolation and identification of the particular chemical agent(s) responsible for the antileishmanial activity observed in the initial plant extract.en_US
dc.description.sponsorshipThis study was supported by NIH grant RC4 AI 076309 (to A. R. Satoskar and A. D. Kinghorn)en_US
dc.description.sponsorshipThe Ohio State University College of Pharmacyen_US
dc.description.sponsorshipThe Ohio State University Medical Centeren_US
dc.language.isoen_USen_US
dc.publisherThe Ohio State Universityen_US
dc.relationAcademic Major: Pharmaceutical Sciencesen_US
dc.relation.ispartofseriesThe Ohio State University. Department of Pharmaceutical Sciences Honors Theses; 2013en_US
dc.subjectleishmaniasisen_US
dc.subjectTaxodium distichumen_US
dc.subjectfractionationen_US
dc.subjectantileishmanial agentsen_US
dc.subjectnatural productsen_US
dc.subjectpharmacognosyen_US
dc.titleBioactivity-Guided Fractionation of Taxodium distichumen_US
dc.typeThesisen_US
dc.description.embargoNo embargoen_US
dc.rights.ccAttribution-NonCommercial-NoDerivs 3.0 United Statesen_US
dc.rights.ccurihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/en_US


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