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dc.contributor.advisorMangel, Stuart
dc.creatorAdelaja, Adewunmi
dc.date.accessioned2012-06-09T03:36:49Z
dc.date.available2012-06-09T03:36:49Z
dc.date.issued2012-06
dc.identifier.urihttp://hdl.handle.net/1811/52075
dc.description.abstractGABA(A) receptors (GABAA Rs) on cone synaptic terminals mediate GABA feedback from horizontal cells to cones and KCC2 expression determines the effect of GABA(A)R activation. Since GABA(A)R expression is dependent on intracellular cAMP and PKA, second messengers which are regulated by the retinal circadian clock, it seems reasonable to postulate that the circadian clock (24-hour) will increase GABA(A)R and KCC2 expression on cone synaptic terminals at night when intracellular cAMP and PKA are elevated. To elucidate the effect of the circadian clock on GABA-mediated feedback from cone horizontal cells to cones, immunohistochemistry was used to visualize the expression of GABA(A)R and KCC2 in goldfish retinas collected at night after dark adaptation and in the day following dark and light adaptation. The results support the hypothesis that the circadian clock increases the expression of GABA(A)Rs and KCC2 on cone terminals at night.en_US
dc.description.sponsorshipNIH grants EY005102 and EY014235 to Dr. Stuart Mangel.en_US
dc.language.isoen_USen_US
dc.publisherThe Ohio State Universityen_US
dc.relation.ispartofseriesThe Ohio State University. College of Biological Sciences Honors Theses; 2012en_US
dc.subjectRetinaen_US
dc.subjectCircadian Clocken_US
dc.subjectChloride Co-transporteren_US
dc.subjectGABAen_US
dc.subjectImmunohistochemistryen_US
dc.subjectImmunocytochemistryen_US
dc.subjectKCC2en_US
dc.subjectDopamineen_US
dc.subjectReceptorsen_US
dc.subjectGoldfishen_US
dc.subjectOuter Plexiform Layeren_US
dc.subjectcAMPen_US
dc.subjectHorizontal Cellsen_US
dc.subjectCone terminalsen_US
dc.subjectDark Adaptationen_US
dc.subjectLight Adaptionen_US
dc.subjectRod-Cone Couplingen_US
dc.titleEffect of the Retinal Circadian Clock on Expression of GABA(A) Receptors and Chloride Co-Transporters by Goldfish Cone Synaptic Terminalsen_US
dc.typeThesisen_US
dc.description.embargoNo embargoen_US


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