Chemokine receptor CXCR4 and CXCR7 as a Novel Target Against Small Cell Lung Cancer
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Publisher:The Ohio State University
Series/Report no.:The Ohio State University. Department of Biochemistry Undergraduate Research Theses; 2012
Small cell lung cancer (SCLC) is a highly aggressive malignancy with a limited spectrum of therapeutic options. We are planning to analyze chemokine receptor 4 (CXCR4) and 7 (CXCR7) as promising and emerging biomarkers for SCLC. Both CXCR4 and CXCR7 have been shown to be highly expressed in various types of cancers. It has also been suggested that CXCR4 expression may be increased in patients with metastatic disease. Recently, enrichment of CXCR4+ stem-like sub-population of cells was observed in tumors treated with cisplatin, suggesting that these populations may be resistant to chemotherapies. The main objective of this study is to determine expression and clinical utility of CXCR4/CXCR7 as novel biomarkers and therapeutic targets for inhibiting SCLC growth and metastasis.