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dc.contributor.advisorCallam, Christopher
dc.creatorDoane, Adam
dc.description.abstractSpiro lactones have had an extensive impact in both medicinal and organismal biology. Since their discovery, various methods for preparing spiro lactones have been studied and investigated. One of these spiro lactones, pyrenolide D, which is one of the four metabolites, A-D, was isolated from Pyrenophora teres by Nukina and Hirota in 1992 and shows cytotoxicity towards HL-60 cells at IC50 4 µg/ mL. The structural determination, via spectroscopic methods, reported that unlike pyrenolides A-C, pyrenolide D contained a rare, highly oxygenated tricyclic spiro-γ-lactone structure and did not contain the macrocyclic lactone seen in the other pyrenolides. The purpose of this project is the determination of a cost effective and efficient synthesis of pyrenolide D from the naturally occurring sugar, D-xylose. Herein we report studies towards the total synthesis of pyrenolide D.en_US
dc.description.sponsorshipChemical Abstracts Serviceen_US
dc.description.sponsorshipThe Ohio State University Department of Chemistryen_US
dc.publisherThe Ohio State Universityen_US
dc.relation.ispartofseriesThe Ohio State University. Department of Chemistry Honors Theses; 2012en_US
dc.subjectOrganic Chemistryen_US
dc.subjectNatural Producten_US
dc.titleStudies toward the Total Synthesis of (+)-Pyrenolide Den_US
dc.description.embargoNo embargoen_US

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