Boronate Urea Activation of Strained Rings
MetadataShow full item record
Publisher:The Ohio State University
Series/Report no.:The Ohio State University. Department of Chemistry Honors Theses; 2012
Reactions catalyzed by small organic molecules through non-covalent interactions are emerging as powerful tools for the synthesis of valuable target molecules. Specifically, hydrogen bond donors (HBDs) are useful non-covalent catalysts able to interact with a variety of functional groups and operate in a number of transformations. Boronate ureas have been identified as a new class of HBDs with enhanced reactivity due to the strategic placement of an internal Lewis acid. Specifically, in comparison to conventional ureas, boronate ureas benefit from lower catalyst loadings, reduced reaction times and access to unique reactivity patterns. To this end, we have discovered boronate ureas operate as catalysts for the ring-opening of strained ring systems, giving rise to valuable building blocks in good yield.
Items in Knowledge Bank are protected by copyright, with all rights reserved, unless otherwise indicated.