Finding the missing KASH
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Publisher:The Journal of Cell Biology - Rockefeller University Press
Citation:Zhou, Xiao, et al. "Novel Plant Sun–Kash Bridges Are Involved in Rangap Anchoring and Nuclear Shape Determination." The Journal of Cell Biology 196.2 (2012): 203-11.
Series/Report no.:2012 Edward F. Hayes Graduate Research Forum. 26th
The nucleus holds and protects the genetic information of a cell. Nuclear positioning is correlated with several important cellular processes, such as cell division, migration and differentiation, and it is essential to the development of organisms ranging from worms to mammals. Nuclear positioning is mediated through a protein complex across the nuclear envelope (NE), formed by the outer nuclear membrane (ONM) KASH proteins and the inner nuclear membrane (INM) SUN proteins. The cytoplasmic part of KASH proteins is associated with the cytoskeleton, and the nucleoplasmic part of SUN proteins is associated with the nucleoskeleton. Meanwhile, in the perinuclear space (PNS), the C-terminal tail of KASH proteins interacts with the SUN domain of SUN proteins. Therefore, KASH-SUN complexes are linkers of the nucleoskeleton to the cytoskeleton (LINC). LINC is conserved from yeasts to humans. However, in plants, only SUN proteins have been identified, leaving plant KASH proteins and the functions of plant SUN proteins a mystery. The purpose of this study is to identify plant KASH proteins and uncover the function of the plant KASH-SUN interaction.
Poster Division: Biological Sciences: 2nd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)
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