Levoamphetamine and Dextroamphetamine: Differential Effect on Aggression and Hyperkinesis in Children and Dogs
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Publisher:American Psychiatric Publishing
Citation:L. Eugene Arnold et al, "Levoamphetamine and Dextroamphetamine: Differential Effect on Aggression and Hyperkinesis in Children and Dogs," The American Journal of Psychiatry 130, no. 2 (1973)
In laboratory experiments with hyperkinetic, untrainable dogs and in a comparison of levoamphetamine, dextroamphetamine, and placebo in children, levoamphetamine and dextroamphetamine were found to be approximately equal in calming an aggressive, hostile dog and in benefiting "unsocialized-aggressive" children; dextroamphetamine was more effective than levoamphetamine in calming "nervousness" and hyperactivity in dogs and in overanxious-hyperkinetic children. These data suggest that in the hyperkinetic syndrome, aggression and hostility may be benefited equally by levoamphetamine or dextroamphetamine via a dopaminergic mechanism, while anxiety and overactivity may be benefited significantly only by the dextro isomer via a norepinephrinergic mechanism.
Rights:© 1973 American Psychiatric Publishing, Inc.
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