A Mathematical Description of the Toxicity of "Sernyl" to Goldfish

Abstract

The toxicity of the drug 1- (1-phenylcyclohexyl) piperidine, "sernyl", to goldfish, Carassius auratus, was tested. Median tolerance limits, median lethal concentrations (LCt 50) and the relation of the quantity Ct to time were calculated. The relation of concentration of sernyl to time of exposure may be expressed by the equation: Ct = 34+ 23t0-43. The results indicate that at higher concentrations of sernyl the LCt 50 is less than at lower concentrations. The value of K = 34 in the above equation provides a new constant for the tolerance of goldfish to serynl.